70 years of Alfasigma corporate history has developed a solid drugs’ pipeline. Sulodexide is a heparin-like therapy with indications in venous and arterial diseases with thrombotic risk. Branded as Vessel in Italy, Aterina in Spain and Vessel Due F all over the world, is an efficacious and safe treatment for Chronic Venous Disease and re-thrombosis prevention w.o. bleeding risk increase. Sulodexide is approved in over 30 countries for venous and arterial diseases with thrombotic risk and diabetic microangiopathies (eye, foot, kidney). Moreover, Sulodexide is recommended in international guidelines for chronic venous ulcer healing (UIP / ESVS 2015, EVF 2018), for Venous Thromboembolism recurrence (ESC 2019) and post-thrombotic syndrome prevention (EVF 2020).